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Atherosclerosis and Heart Disease

New Study published in the Journal of the American Medical Association

The news about omega-3 benefits keeps coming! The evidence continues to grow stronger. Patients with coronary heart disease showed relatively longer “telomeres” when taking omega-3. As we age, our cells continue to divide and the “telomeres” shrink in size and thus is a marker of biological age. Shorter telomeres have been correlated with death and heart failure in several studies.

In a study published in this week’s JAMA (Journal of the American Medical Association), researchers measured telomere length in over 600 patients over 5 years. The study found that people with high levels of omega-3 fatty acids in their system had significantly less shrinkage in telomeres over five years, as compared with patients with lower omega-3 levels.

“What we’re demonstrating is a potentially new link between omega-3 fatty acids and the aging process,” said Ramin Farzaneh-Far, a clinical cardiologist and assistant medical professor at UCSF and San Francisco General Hospital who is the lead author of the research.

This comes just after other recent studies showing the benefits of omega-3 to heart patients. Just in August of 2009 a study was published in the August 11, 2009, issue of the Journal of the American College of Cardiology, which reviewed data on four trials involving almost 40,000 participants and overwhelmingly confirmed the benefits of omega-3 fatty acids in the prevention of cardiovascular disease, in treatment after heart attack and, most recently, in heart failure patients.

The researchers conclude that the current recommendations on omega-3 fatty acids don’t change and the following guide from American Heart Association (AHA) on appropriate dosage levels is very much valid:

The AHA notes that patients taking more than 3 grams of omega-3 fatty acids from capsules should only do so under a physician’s care.  High intakes could cause excessive bleeding in some people.

Sources: Journal of American Medical Association. American Heart Association and American College of Cardiology, and The Wall Street Journal

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According to Bradley West, ND, Nordic Naturals Research Advisor, “in traditional delivery systems like soft gels, the omega-3s in cod liver oil need to be gradually broken down by stomach acids in order to be absorbed in the small intestine. With the effervescent technology in place, the omega-3s can be absorbed and enter the blood stream faster – in as little as 15 minutes.” In addition to quicker absorption, the product is also easy on the stomach. The organic food acid combines with the carbonate, which buffers the effervescent solution to a normal pH. “Omega-3 Effervescent is the ultimate solution for individuals with digestive challenges, or those that find it hard to swallow soft gels, as well as the perfect way to ensure compliance when traveling,” adds Dr. West.

Nordic Naturals Omega-3 Effervescent contains cod liver oil made from Arctic cod harvested in a sustainable manner from Norwegian waters. Arctic cod is a flourishing fish population that has the highest DHA content of any cod species, as well as naturally occurring vitamins A and D. The formula contains added natural vitamin D3 for enhanced bone, mood and immune support. Sweetened with stevia in creamy orange flavor, the product has no oily feel or texture and never smells or tastes fishy. Omega-3 Effervescent is available in 7 and 21 count packages and can be used by both children and adults. More information is available at www.drinkyouromegas.com.

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Salmon

A new study, published in the August 11, 2009, issue of the Journal of the American College of Cardiology, reviewed data on four trials involving almost 40,000 participants and overwhelmingly confirmed the benefits of omega-3 fatty acids in the prevention of cardiovascular disease, in treatment after heart attack and, most recently, in heart failure patients.  

“This isn’t just hype; we now have tremendous and compelling evidence from very large studies, some dating back 20 and 30 years, that demonstrate the protective benefits of omega-3 fish oil in multiple aspects of preventive cardiology,” said Carl Lavie, M.D., F.A.C.C., medical director of Cardiac Rehabilitation and Prevention, Ochsner Medical Center, New Orleans, LA, and lead author of the article. “The strongest evidence of a cardioprotective effect of omega-3s appears in patients with established cardiovascular disease and following a heart attack with up to a 30 percent reduction in CV-related death.”

DHA (docosahexaenoic acid) and EPA (eicosapentaenoic acid), the long-chain fatty acids in the omega-3 family found abundant in fish have the most compelling evidence. According to Dr. Lavie, EPA and DHA work by getting into the membranes of cells and, in doing so, may help to improve the heart’s electrical activity, vascular tone, plaque stabilization and blood pressure.

Based on these findings, and because the body does not produce its own essential fatty acids, the authors recommend that healthy individuals consume 500 mg daily of omega-3 fish oil containing EPA and DHA, and people with known heart disease or heart failure aim for at least 800 to 1,000 mg daily.

“There are clear health and heart benefits associated with increasing one’s intake of foods that are rich in Omega-3s, including oily fish like salmon, sardines, trout, herring, and oysters” said Dr. Lavie.

Authors say further studies are needed to investigate and determine optimal dosages, as well as the ratio of DHA to EPA for maximal heart protection in patients.

Source: American College of Cardiology

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Joint Inflammation

Most scientists now agree that fish oil benefits various inflammatory conditions like arthritis, heart disease etc. However, the mechanism of how fish oil benefits these conditions has been a mystery. Now, in a joint study between British and American scientists that recently was published in the journal Nature, there are clues to how fish oil helps arthritis patients in particular.

The answer seems to lie in that the body converts DHA, a key omega-3 fatty acid found in fish oils into Resolvin D2, a chemical which has been show to have anti-inflammatory properties.

Professor Mauro Perretti, from Queen Mary, University of London, who led the UK team, said: “We have known for some time that fish oils can help with conditions like arthritis which are linked to inflammation. What we’ve shown here is how the body processes a particular ingredient of fish oils into resolvin D2.”

“We’ve also looked in detail at this chemical, determining at least some of the ways it relieves inflammation. It seems to be a very powerful chemical and a small amount can have a large effect.”

Quoting the authors, “This research is important because it explains at least one way in which fish oils can help in different types of arthritis. We can also work on this chemical and see if it can be used not only to treat or even prevent arthritis, but also as a possible treatment for a variety of other diseases associated with inflammation.”

Source: Nature 461, 1287-1291 (29 October 2009) | doi:10.1038/nature08541; Received 18 August 2009; Accepted 21 September 2009