In a recent study, researchers studied the combined effects of aspirin with EPA, and DHA omega-3 fatty acids (fish oil) on their anti-inflammatory properties. They studied the ingestion of EPA and DHA, with and without aspirin and measured levels of inflammatory markers such as cytokines and angiogenesis factors more than aspirin alone and before aspirin was ingested. The study used a single-dose of aspirin of 650 mg on day 1 followed by EPA+DHA 3.4 grams per day for days 2-29, and aspirin with EPA+DHA on day 30.
The results indicated that Aspirin alone had no effect on any factor versus baseline, but EPA+DHA, with and without aspirin, significantly reduced concentrations of 8 of 9 factors. Although EPA+DHA plus aspirin reduced concentrations of a subset of the factors compared to baseline, neither aspirin alone nor the combination significantly reduced the level of any of the markers more robustly than EPA+DHA alone. These data suggest that EPA+DHA has more pronounced effects against inflammation and angiogenesis than aspirin. The implications of these findings for the use of combined therapy for cardiovascular disease remain to be studied further.